Another explanation is the postantibiotic submic effect pa sme, which also takes into account the effect of subinhibitory concentrations after exposure to suprainhibitory concentrations 2, 1219. Postantibiotic effect pae is the persistent suppression of bacterial growth following limited exposure to an antibiotic. Postantibiotic effect pae defines the potential of a drug to delay regrowth of a bacterial population after. In this particular experiment the postantibiotic effect was 2. Postantibiotic effects paes and postantibiotic subinhibitory effects pa smes on bacteria may provide additional, valuable information for the rational use of a drug in clinical practice. In this study tilmicosin was the most active antibiotic tested against p. L3h1 thymidine for determination of postantibiotic effects 101 cert determined by hlthymidine incorporation, the same definition was used, with c being the time needed for the control to increase 1 loglo countsmin after drug removal and t representing the time needed for the exposed culture to reach the same radioactivity. The postantibiotic effect of ciprofloxacin springerlink. Postantibiotic effect was studied by incubating a strain from each species in serum samples obtained 1 and 6 h after both regimens for 0. Postantibiotic effects and bactericidal activities of levo. Vancomycin is considered as gold standard in treating lifethreatening infections.
Postantibiotic and postbetalactamase inhibitor effect of. Postantibiotic effects of daptomycin against 14 staphylococcal and. Postantibiotic effect an overview sciencedirect topics. The term postantibiotic effect has been used to describe this phenomenon because it. The postantibiotic effect in the treatment of experimental meningitis caused by. Original article postantibiotic effect of meropenem in combination with gentamicin or sparfloxacin on grampositive and gramnegative organisms anna ferraral, conceiciio dos santos2 and monica cimbro cattedra dl chemioterapia, universiti d pavia, and 21rccs policlinico s. To determine the postantibiotic effect pae on some grampositive and gram. The postantibiotic effect pae is a pharmacodynamic pa rameter contributing to the choosing of antibiotic dosing reg imens. Postantibiotic effects and postantibiotic submic effects. Postantibiotic, postantibiotic submic, and subinhibitory. Determination of in vitro postantibiotic effects in. The postantibiotic effect annals of internal medicine american. The persistent suppression of bacterial growth after exposure to antimicrobial agents has been defined as the postantibiotic effect pae. Postantibiotic, postantibiotic submic, and subinhibitory effects of pge9509924, ciprofloxacin, and levofloxacin article pdf available in antimicrobial agents and chemotherapy 4710.
A health education course was organized on prescribing aminoglycoside antibiotics. The list of acronyms and abbreviations related to pae postantibiotic effect. Kuninpersistent effect of antibiotics on staphylococcus aureus after exposure for limited periods of time. Aim to philosophy and history of science beyond the kuhnian paradig investigate the postantibiotic effects pae of different classes of philips pfl6606 pdf antimicrobials against five. Pdf aminoglycoside antibiotics and postantibiotic effects. The postantibiotic effect in the treatment of experimental. The study of the delayed regrowth of surviving bacteria following cessation of antibiotic administration, the postantibiotic effect pae, and related phenomena such as the integration of the pharmacological and antimicrobial profiles of drugs became known as pharmacodynamics and is increasingly being applied to the design of dose regimens mackenzie and gould 1993.
Pdf the postantibiotic effect of fusidic acid against. Postantibiotic effect of azithromycin and erythromycin on. Postantibiotic effect of meropenem in combination with. The slide sets may be used only by the person who downloads or purchases them and only for. The relevance of a postantibiotic effect in the treatment of pneumococcal meningitis was evaluated in a rabbit model. Pdf postantibiotic and postantibiotic submic effects of.
Pdf comparative in vitro activities and postantibiotic. Postantibiotic effect of roxithromycin, erytfaromycin, and. Postantibiotic effects and postantibiotic submic effects of roxithromycin, clarithromycin, and azithromycin on respiratory tract pathogens. Postantibiotic effects and bactericidal activities of. Pdf postantibiotic effects and postantibiotic submic. Download fulltext pdf aminoglycoside antibiotics and postantibiotic effects.
1107 500 663 565 100 1147 984 1183 957 742 483 1343 1513 487 127 1025 899 1198 1493 1426 923 1290 1264 1093 750 203 624 1401 510 550 1472 404